Neurodegenerative disorders represent a class of progressive diseases that lead to irreversible loss of neuronal function within the brain and central nervous system. Among them, Huntington’s disease (HD) is a fatal neuropsychiatric condition, with its prevalence in India comparable to that observed in Western populations. Despite significant advances in research, no effective curative therapy exists to arrest or reverse disease progression. A major challenge in HD management lies in the restricted permeability of therapeutic agents across the blood–brain barrier (BBB), which limits drug availability within the central nervous system. Moreover, conventional pharmacological treatments are often associated with adverse systemic effects. In the present investigation, an attempt was made to develop Phyllanthus emblica extract–loaded gelatin nanospheres as a novel nanoformulation for potential use in the treatment of Huntington’s disease. Pre-formulation studies were carried out to determine the solubility and physicochemical characteristics of the extract. FTIR and UV analyses confirmed the absence of drug–polymer interactions, showing a distinct absorption peak at 273 nm. The nanospheres (formulations F1–F4) were prepared by the solvent displacement method and evaluated for particle size, surface morphology, zeta potential, entrapment efficiency, and drug loading. Entrapment efficiency values ranged from 40.61% to 80.21%, while drug loading varied between 18.79% and 50.33%. Among all, formulation F2 exhibited optimal characteristics with a sustained drug release profile, showing 10% release at 1 hour and 37% release at 6 hours. The antioxidant potential of the nanospheres was further assessed by DPPH assay, revealing strong free radical scavenging activity. Overall, the results indicate that Emblica officinalis–loaded gelatin nanospheres may serve as an effective, biocompatible nanocarrier for targeted brain delivery in the management of Huntington’s disease. Further in vivo investigations and optimization are warranted to establish their therapeutic efficacy and clinical relevance.